Journal of General Virology

Fig. 1. Schematic diagram of virus entry. Negative-sense RNA viruses bind to host cell receptors via viral surface glycoproteins. (A) pH-independent pathway. Fusion of the viral membrane with the plasma membrane releases RNP complexes into the cytoplasm. (B) pH-dependent pathway. Viruses are internalized by receptor-mediated endocytosis. The low pH in late endosomes triggers conformational changes in the viral glycoproteins that lead to the fusion of the viral and endosomal membranes and the subsequent release of RNP complexes into the cytosol.

Back to article

0001-8400 © 2002 SGM